Our response to study linking menopause and dementia risk

Our response

The results of a large-scale UK study ‘Emotional and cognitive effects of menopause and hormone replacement therapy’ have shown that the menopause is linked to changes in the brain similar to those seen in Alzheimer’s disease. The Cambridge University study, which analysed data from 125,000 women, assessed associations between menopause, the use of Hormone Replacement Therapy (HRT), and outcomes related to mental health, cognition, and the study of the structural measures of the brain. 

The study findings suggest that menopause is linked to “adverse mental health outcomes and reductions in grey matter volume in key brain regions”, and the use of HRT did not alleviate these changes. 

We understand that the results of this survey will be concerning for women. We already know that women are more likely to be affected by dementia – they are twice as likely as men to develop Alzheimer’s disease and dementia is currently the leading cause of death for women in Scotland. 

Throughout life, women often have different experiences than men. Some of these differences are biological, such as menstruation, pregnancy, and menopause. Others are shaped by societal roles, including education, career opportunities, and lifestyle, many of which can influence dementia risk. 

We must however welcome the fact that studies like this are researching women’s brain health and dementia. Earlier this month, the Scottish Government published Phase 2 of the Women’s Health Plan, which includes ‘brain health’ for the first time thanks to campaigning from some of our Active Voice members – this a vital step forward. It is only with investment in research that progress can be made in understanding the causes of Alzheimer’s disease and other dementias. 

Brain Awareness Week, an annual global campaign to raise awareness of brain science and research, will take place between 16-22 March and our theme for this year will be ‘Women’s brain health’. We will be sharing some special content on our website and social media channels throughout that week.  For more information on looking after your brain health and risk reduction, visit www.brainhealth.scot/